How I Treat: STAT3 hyper IgE syndrome
Cliodhna Ella Murray, Eyad Jannoud, Seraina Prader, Bodo Grimbacher · 2026
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Description
Cliodhna Ella Murray and co-authors offer 2026 guidance on treating STAT3 hyper IgE syndrome, a rare inherited immune disorder. Faulty STAT3 signaling causes eczema, repeated skin and lung infections, and very high IgE levels. Effects also reach bones, teeth, blood vessels, and the gut across a lifetime.
Drawing on more than 25 years of care for over 20 adults at one center, plus a review of published evidence, the authors lay out diagnosis, baseline checks, and day-to-day management. They flag where advice rests on experience with similar disorders rather than direct proof. Clinicians gain a practical pathway for a condition that previously had few concrete recommendations.
Catalog record
| CREATOR | Cliodhna Ella Murray, Eyad Jannoud, Seraina Prader, Bodo Grimbacher |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |