Cancer vaccines: comprehensive review
Rachael E Clifford, Nichola Manu, Qian Yang, Zeeshan Arif, David Aggen, Michael E Bryan, Aditi Gupta, Heather Shaw, David Church, Philippa Corrie, Natalia Savelyeva, Christian Ottensmeier, Sarah Danson, Robert Jones · 2026
Read Cancer vaccines: comprehensive review by Rachael E Clifford, Nichola Manu, Qian Yang, Zeeshan Arif, David Aggen, Michael E Bryan, Aditi Gupta, Heather Shaw, David Church, Philippa Corrie, Natalia Savelyeva, Christian Ottensmeier, Sarah Danson, Robert Jones (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13220758.txt.
Description
Vaccines taught the immune system to prevent cancer's infectious causes; now researchers ask them to treat cancer itself. Rachael Clifford and co-authors review the field in 2026, covering vaccine designs, trial results, and what the approach means for surgical oncology.
The strongest signals come from tumors with many mutations — melanoma, lung, and bladder cancers — where personalized vaccines paired with checkpoint inhibitors improved relapse-free survival in adjuvant trials. Even pancreatic cancer, long called cold, showed responses. Ready-made vaccines against shared tumor antigens scale easily but fight tolerance and weak targeting. The review sees vaccines joining surgery and drug therapy in combined strategies, especially around the time of operation. In that window they may widen the immune attack through antigen spreading and hold disease off longer. Hard parts remain: cold tumors that shrug off immune attack, and the cost of making each vaccine to order.
Catalog record
| CREATOR | Rachael E Clifford, Nichola Manu, Qian Yang, Zeeshan Arif, David Aggen, Michael E Bryan, Aditi Gupta, Heather Shaw, David Church, Philippa Corrie, Natalia Savelyeva, Christian Ottensmeier, Sarah Danson, Robert Jones |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |