Mesenchymal stem cell-derived extracellular vesicles for osteochondral defect regeneration: a systematic review and meta-analysis of preclinical studies
Yixin Wen, Guangran Meng, Shengtao Yang, Hongjun Mei · 2026
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Description
Yixin Wen and co-authors pool the animal evidence for stem cell vesicle therapy in cartilage repair in a 2026 review and meta-analysis. Mesenchymal stem cells release parcels, extracellular vesicles, that carry their regenerative signals without transplanting living cells. Studies of these vesicles for osteochondral defects, damage spanning cartilage and bone beneath, have multiplied.
Searching four databases to January 2025, the reviewers found nineteen studies that met criteria. Vesicle treatment improved cartilage repair scores at three and six months and raised the amount and thickness of new bone beneath the repair, alongside better scores for cartilage and subchondral bone. No subgroup explained the differences between studies, and sensitivity checks left the conclusions intact. The authors are candid about the research base: mostly animal models, methods for preparing and dosing vesicles, and signs of publication bias. Large-animal work, standard protocols, and safety data are their prerequisites for human trials.
Catalog record
| CREATOR | Yixin Wen, Guangran Meng, Shengtao Yang, Hongjun Mei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |