Biomimetic proteolipid vesicles delivering small activating RNA to activate the macrophage immunotherapy for the treatment of lung cancer
Hui Yu, Jiandong Zhang, Qiuyun Liu, Ling Liu, Yingying Le, Huiyu Cen, Weijie Peng, Juyan Wei, Sijia Liu, Aiping Qin, Yuyan Qin, Xiufeng Li, XiaoGang Xu, Lingmin Zhang, Lu Liang · 2026
Read Biomimetic proteolipid vesicles delivering small activating RNA to activate the macrophage immunotherapy for the treatment of lung cancer by Hui Yu, Jiandong Zhang, Qiuyun Liu, Ling Liu, Yingying Le, Huiyu Cen, Weijie Peng, Juyan Wei, Sijia Liu, Aiping Qin, Yuyan Qin, Xiufeng Li, XiaoGang Xu, Lingmin Zhang, Lu Liang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13220422.txt.
Description
Hui Yu and a large team of co-authors published a study in 2026 on reprogramming the immune cells that shield lung tumors. Macrophages inside tumors usually settle into a healing mode that protects the cancer. Flipping them into attack mode is a popular strategy, and the team built a delivery particle to do it with small RNAs that switch genes on rather than off.
Genes for two reprogramming switches were packaged in a metal-organic core, wrapped in a hybrid membrane, and tagged with a peptide that homes to tumor macrophages. In mice the particles circulated long, gathered in tumors, and flipped macrophages to the attack state. T cells flooded in, and tumor cells exposed to the treated macrophages lost their ability to migrate and invade. A camouflaged courier, in short, turned bodyguards into attackers.
Catalog record
| CREATOR | Hui Yu, Jiandong Zhang, Qiuyun Liu, Ling Liu, Yingying Le, Huiyu Cen, Weijie Peng, Juyan Wei, Sijia Liu, Aiping Qin, Yuyan Qin, Xiufeng Li, XiaoGang Xu, Lingmin Zhang, Lu Liang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |