Multifunctional Lipid Nanoparticles Remodeling Tumor Immune Microenvironment for Breast Cancer Chemo-Immunotherapy
Wei Jiang, You Zheng, Zhouhong Jing, Xiangling Yu, Huiying Fang · 2026
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Description
Wei Jiang, You Zheng, Zhouhong Jing, Xiangling Yu, and Huiying Fang build a two-drug nanoparticle for breast cancer, in a 2026 study. Breast tumors often shield themselves with an immune-suppressing neighborhood, so drugs alone underperform. The team wrapped two agents in fat-based particles coated with a folic acid and chitosan layer: doxorubicin, a classic chemotherapy drug, and resiquimod, an immune activator. The coating helps the particles home to cancer cells.
The particles were checked for size, charge, and drug loading, then tested on cells for uptake and killing power. In mice carrying breast tumors, the treatment's effect and safety were measured, along with changes in immune cell mix inside the tumor. The design aims to hit the tumor and wake its immune surroundings at once.
Catalog record
| CREATOR | Wei Jiang, You Zheng, Zhouhong Jing, Xiangling Yu, Huiying Fang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |