Integrated Ferroptosis and Immune Features Are Associated With Overall Survival in Bladder Urothelial Carcinoma: A TCGA-Based Analysis
Lei Zhang, Zhengzuo Sheng · 2026
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Description
Lei Zhang and Zhengzuo Sheng test whether combining iron-death and immune signatures sharpens survival prediction in bladder cancer, in a 2026 analysis of Cancer Genome Atlas. Bladder urothelial carcinoma is common and its course varies widely, so any prognostic signal beyond stage and grade is welcome. Ferroptosis, death by iron-driven membrane damage, and immune activity shape tumor behavior, and the authors scored tumors on each.
Neither score alone separated survivors from non-survivors. In models the immune score leaned protective and the ferroptosis score leaned risky without reaching significance, and their relationship with survival bent for the immune score. Bolting both scores onto a clinical model improved prediction, and the same pattern held in two validation cohorts and in sensitivity checks adding grade. The authors label the work exploratory and hypothesis-generating: the combined signature adds a little information, but it is not ready to steer treatment.
Catalog record
| CREATOR | Lei Zhang, Zhengzuo Sheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |