Decitabine Induces Subtype-Specific Epigenomic Remodeling and Perturbs Age-Associated Regulatory CpGs in Breast Cancer
Areez Shafqat, Itika Arora, Arshiya Akbar, Mohammed Alfuwais, Safiah Aldubaisi, Mohammad Imran Khan, Ahmed Abu-Zaid, Firoz Ahmed, Ahmed Yaqinuddin · 2026
Read Decitabine Induces Subtype-Specific Epigenomic Remodeling and Perturbs Age-Associated Regulatory CpGs in Breast Cancer by Areez Shafqat, Itika Arora, Arshiya Akbar, Mohammed Alfuwais, Safiah Aldubaisi, Mohammad Imran Khan, Ahmed Abu-Zaid, Firoz Ahmed, Ahmed Yaqinuddin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13219924.txt.
Description
Areez Shafqat and colleagues examine how the drug decitabine rewires two different breast cancer cell lines in a 2026 study. Decitabine blocks the enzymes laying down methylation, the marks that silence genes, and cancers carry different marking patterns by subtype. Whether effects follow the subtype, or march to one drum, matters for how it is tested in patients.
Using a dataset, the team compared treated and untreated T-47D, a luminal line, with JIMT-1, a HER2 line resistant to trastuzumab. Decitabine stripped methylation from twelve hundred sites in JIMT-1 and over nineteen hundred in T-47D, switching on hundreds of genes in each. The activated programs diverged, though: immune signaling in one, matrix and collagen pathways in the other. One gene rose while its promoter gained methylation, defying the rulebook. It disturbed the sites used by epigenetic clocks. Survival analyses in cohorts tied 100-plus genes to outcomes in hormone-positive disease.
Catalog record
| CREATOR | Areez Shafqat, Itika Arora, Arshiya Akbar, Mohammed Alfuwais, Safiah Aldubaisi, Mohammad Imran Khan, Ahmed Abu-Zaid, Firoz Ahmed, Ahmed Yaqinuddin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |