An in-depth analysis of the molecular changes induced by short-term calorie restriction before living kidney donation
Martin R Späth, Sita Arjune, Katrin Bohl, Markus M Rinschen, Christine S Falk, Philipp Antczak, Franziska Grundmann, Torsten Kubacki, K Johanna R Hoyer-Allo, Michael Ignarski, Felix C Koehler, Kathrin Kaufmann, Malte P Bartram, Tristan Wagner, Michael Thomas, Jan Wilm Lackmann, Adam Wahida, Christop · 2026
Read An in-depth analysis of the molecular changes induced by short-term calorie restriction before living kidney donation by Martin R Späth, Sita Arjune, Katrin Bohl, Markus M Rinschen, Christine S Falk, Philipp Antczak, Franziska Grundmann, Torsten Kubacki, K Johanna R Hoyer-Allo, Michael Ignarski, Felix C Koehler, Kathrin Kaufmann, Malte P Bartram, Tristan Wagner, Michael Thomas, Jan Wilm Lackmann, Adam Wahida, Christop (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13219448.txt.
Description
Martin R. Späth and colleagues examine what a week of calorie restriction does inside the bodies of kidney donors in a 2026 study. In animals, eating much less before a transplant protects kidneys from the blood-flow injury, and ageing erodes the resilience that makes protection possible. Whether it works in people, and through which molecules, was unknown.
Twelve donors were assigned to a formula diet supplying half their needs for seven days before donation, or to eating freely. Restriction was tolerated, produced weight loss, and did not raise kidney injury or complications after donation. Fat tissue, arteries, ureter, kidney, blood, and urine samples told a molecular story. Fat breakdown and protein housekeeping rose, insulin signaling quieted, inflammatory factors fell in vessel and ureter tissue, and some effects differed by sex. The authors call the work hypothesis-generating and propose calorie restriction mimetics as a route to organ protection.
Catalog record
| CREATOR | Martin R Späth, Sita Arjune, Katrin Bohl, Markus M Rinschen, Christine S Falk, Philipp Antczak, Franziska Grundmann, Torsten Kubacki, K Johanna R Hoyer-Allo, Michael Ignarski, Felix C Koehler, Kathrin Kaufmann, Malte P Bartram, Tristan Wagner, Michael Thomas, Jan Wilm Lackmann, Adam Wahida, Christop |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |