Molecular mechanisms of autophagy-lysosomal pathway dysfunction in neurodegenerative diseases and therapeutic strategies for lysosomal repair: a review
Weilin Wang, Xianguo Meng · 2026
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Description
Weilin Wang and Xianguo Meng review how a broken cell cleanup pathway drives brain diseases, and how to repair it, in an overview from two thousand twenty-six. The pathway, named in the title, breaks down worn proteins and keeps cells in balance. Its failure is now seen as a core fault in many degenerative brain diseases.
The review maps how damage to the pathway's lysosome step tangles protein disposal. It weighs how rust-like protein damage and disposal failure feed each other. Repair strategies aimed at the lysosome are then graded for clinic potential. Target lists for drug screening close the piece.
Catalog record
| CREATOR | Weilin Wang, Xianguo Meng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 99 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |