Comparison between liquid and tablet formulations in the treatment of congenital hypothyroidism
Anna Parzianello, Erika Cantarelli, Elisa Bortolamedi, Egidio Candela, Alessandra Cassio, Federico Baronio, Marcello Lanari, Rita Ortolano · 2026
Read Comparison between liquid and tablet formulations in the treatment of congenital hypothyroidism by Anna Parzianello, Erika Cantarelli, Elisa Bortolamedi, Egidio Candela, Alessandra Cassio, Federico Baronio, Marcello Lanari, Rita Ortolano (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13219096.txt.
Description
Anna Parzianello and colleagues compare three liquid and tablet forms of levothyroxine in babies with hypothyroidism in a 2026 study from Bologna, Italy. Babies born without enough thyroid hormone need replacement from the first days to protect brain development, and parents can give it as tablets, drops, or a solution. Whether the form changes hormone control was unclear.
The study followed eighty-two children picked up by newborn screening between 2019 and 2024, grouped by the formulation their doctors used in care, and tracked them to age three. The solution group ran higher thyroid-stimulating hormone than the tablet group, and at twelve months the drops group more often dipped below the target range for free hormone. No formulation caused side effects. The three forms proved equally effective at normalizing and holding hormone levels in range, and the authors say the differences deserve further study before anyone declares a winner.
Catalog record
| CREATOR | Anna Parzianello, Erika Cantarelli, Elisa Bortolamedi, Egidio Candela, Alessandra Cassio, Federico Baronio, Marcello Lanari, Rita Ortolano |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |