Thermosensitive in situ Hydrogel Based on Benzalkonium Chloride-Loaded Selenium-Doped Mesoporous Silica Nanoparticles for Diabetic Chronic Wound Treatment

Description

Yukun Liu and co-authors engineer a temperature-sensitive gel dressing loaded with drug-carrying nanoparticles for diabetic chronic wounds in a 2026 biomaterials study. Diabetic wounds stall because infection, oxidative stress, weak blood vessel growth, and unresolved inflammation attack at once, and plain dressings cannot address all four. The team's gel is liquid when cool and sets in place on the wound.

The dressing combines a PF127 gel base with mesoporous silica nanoparticles doped with selenium and loaded with the antiseptic benzalkonium chloride. In lab tests it killed Staphylococcus aureus and Escherichia coli, lowered reactive oxygen inside cells, helped blood vessel cells to migrate and form tubes, and calmed inflammatory signals. In diabetic mice the gel sped wound closure, increased collagen deposition and new vessel growth, and eased inflammation. The authors credit the benefit to restored chemical balance in the wound plus joint control of inflammation and vessel growth.

Catalog record

Source: https://europepmc.org/articles/PMC13218975