Macrophage metabolic reprogramming in sepsis-associated acute lung injury: mechanisms and therapeutic strategies
Ran Pan, Yiyi Sun, Lu Chen, Jianping Pan, Junping Guo · 2026
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Description
Ran Pan and four co-authors review how immune cells rewire their fuel use in sepsis-damaged lungs, in a 2026 paper. Sepsis, the body's runaway response to infection, often injures the lungs and kills despite care.
The cells in focus are macrophages, the lung's resident defenders. Attack-mode macrophages burn sugar fast and rest their powerhouses. Repair-mode ones do the opposite, burning fat for steady energy. The review names the enzymes and signals that flip the switch. In sepsis the pattern shifts over time: early on, sugar burning dominates; later, the repair machinery falters. Drugs, natural compounds, and new delivery tricks that push cells back toward repair are surveyed as treatments.
Catalog record
| CREATOR | Ran Pan, Yiyi Sun, Lu Chen, Jianping Pan, Junping Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |