The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis
Sina C. Rosenkranz, Joana F. da Rocha, Luis Moreira, Pius Schlachter, Jasmina Bier, Kaela Healy, Daniela Neves Silva, Mohamed Ariff Iqbal, Marjan Gharagozloo, Yueyue Xiong, Matthew A. Murphy, Helena C. Lichtenfeld, Lukas Raich, Michaela Schweizer, Asude Ertaş, Marcel S. Woo, Vanessa Vieira, Samuel E · 2026
Read The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis by Sina C. Rosenkranz, Joana F. da Rocha, Luis Moreira, Pius Schlachter, Jasmina Bier, Kaela Healy, Daniela Neves Silva, Mohamed Ariff Iqbal, Marjan Gharagozloo, Yueyue Xiong, Matthew A. Murphy, Helena C. Lichtenfeld, Lukas Raich, Michaela Schweizer, Asude Ertaş, Marcel S. Woo, Vanessa Vieira, Samuel E (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13218937.txt.
Description
Sina C. Rosenkranz and a team show that the exercise hormone irisin protects tissue in a model of multiple sclerosis, in a 2026 study. Exercise is one of the few interventions known to slow decline in multiple sclerosis, but the molecules carrying that benefit were unknown. Irisin, released from muscle during activity, was a candidate.
Mice with the experimental autoimmune encephalomyelitis model of the disease ran on wheels and were protected against nerve damage, yet mice unable to make irisin lost protection. Injecting irisin raised its blood levels and reduced clinical symptoms and neuron loss in animals. The hormone did not change immune responses in the body or the nervous system. Instead it switched on a protective gene program inside spinal cord neurons, preserved their synapses and energy production, and appeared to bind motor neurons directly. They propose irisin, or a drug mimicking it, as a therapy for multiple sclerosis.
Catalog record
| CREATOR | Sina C. Rosenkranz, Joana F. da Rocha, Luis Moreira, Pius Schlachter, Jasmina Bier, Kaela Healy, Daniela Neves Silva, Mohamed Ariff Iqbal, Marjan Gharagozloo, Yueyue Xiong, Matthew A. Murphy, Helena C. Lichtenfeld, Lukas Raich, Michaela Schweizer, Asude Ertaş, Marcel S. Woo, Vanessa Vieira, Samuel E |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |