Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction
Jiawen Duan, Lingyu Jiang, Kunlin Hu, Huirong Shi, Xinyu Chi, Weiting Feng, Guodong Wang, Shulin Xiang, Bin Xiong · 2026
Read Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction by Jiawen Duan, Lingyu Jiang, Kunlin Hu, Huirong Shi, Xinyu Chi, Weiting Feng, Guodong Wang, Shulin Xiang, Bin Xiong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13218904.txt.
Description
Jiawen Duan and eight co-authors decode sepsis's immune chaos with layered omics, then treat it with a two-pronged drug pair, in a 2026 study. Sepsis kills through a storm of inflammation plus failed repair, and single-target drugs keep failing.
Patient data showed inflammatory white cells swelling while protective B and killer cells thinned. Guided by those maps, the team built combos hitting inflammation and a regeneration pathway together. The better pair, C2, quieted inflammatory genes, raised calming ones, and eased organ injury in mice. Seven-day survival jumped from 20 percent untreated to 70 percent. Cell and animal tests agreed on the mechanism. A dual strategy, the authors argue, matches the disease's dual nature.
Catalog record
| CREATOR | Jiawen Duan, Lingyu Jiang, Kunlin Hu, Huirong Shi, Xinyu Chi, Weiting Feng, Guodong Wang, Shulin Xiang, Bin Xiong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |