Multiscale Convergence of Signaling, Epigenetic, and Environmental Networks in Mammalian Palatogenesis and Cleft Palate Pathogenesis
Hyung-Jin Won, Beomjong Song, Yujeong Song, Jeong-Oh Shin · 2026
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Description
Hyung-Jin Won and co-authors review how the roof of the mouth forms, and how it can fail, in a 2026 paper. Cleft palate is among the most common birth defects. It starts when crest cells that build the face mishandle growth cues.
The review walks through each stage: shelf growth, lift, and fusion. Signal paths with names like Wnt, Fgf, and Shh steer the work, acting as both growth drivers and niche keepers. Gene-setting layers, from DNA marks to small RNAs, guard cell identity. Smoke, alcohol, and low folate can break these programs. New tools, from single-cell maps to gene editing, may one day fix clefts before birth or regrow tissue after.
Catalog record
| CREATOR | Hyung-Jin Won, Beomjong Song, Yujeong Song, Jeong-Oh Shin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |