A three-dimensional shear dependent continuum model of platelet aggregation under flow
David Montgomery, Eric S. Barrientos, Jake M. Grdadolnik, Kelli Hendrickson, Aaron L. Fogelson, Keith B. Neeves, Karin Leiderman · 2026
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Description
David Montgomery and six colleagues build a three-dimensional model of blood platelet clumping under flow, in a paper dated twenty twenty-six. Clumping seals wounds but can also block vessels. A stringy protein, von Willebrand factor, helps platelets stick in ways that depend on flow speed. Their model tracks seven platelet states and the binding rules at several flow rates.
The model was tuned on chip experiments at two flow speeds. It then matched clump growth and channel blocking in straight and body-like shapes, even at very high flow. It also rebuilt the core-and-shell layout seen in real clots. The work links chip data to how clots grow in the body.
Catalog record
| CREATOR | David Montgomery, Eric S. Barrientos, Jake M. Grdadolnik, Kelli Hendrickson, Aaron L. Fogelson, Keith B. Neeves, Karin Leiderman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |