Modulate Obesity and relateD metabolic complIcations For Yielding improvements in IBD outcomes (MODIFY-IBD): consensus on obesity and cardiometabolic comorbidities in inflammatory bowel disease using systematic reviews and the RAND/UCLA appropriateness method

Jalpa Devi, Sami Samaan, Priya Sehgal, Mouhand Mohamed, Matthew Vincent, Shannon Coombs, Michelle Doering, Edward L Barnes, Amanda M Johnson, Andres J Yarur, Parakkal Deepak · 2026

Read Modulate Obesity and relateD metabolic complIcations For Yielding improvements in IBD outcomes (MODIFY-IBD): consensus on obesity and cardiometabolic comorbidities in inflammatory bowel disease using systematic reviews and the RAND/UCLA appropriateness method by Jalpa Devi, Sami Samaan, Priya Sehgal, Mouhand Mohamed, Matthew Vincent, Shannon Coombs, Michelle Doering, Edward L Barnes, Amanda M Johnson, Andres J Yarur, Parakkal Deepak (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13218099.txt.

Description

Jalpa Devi and co-authors describe the MODIFY-IBD initiative in a 2026 protocol, a consensus project on obesity and heart-metabolic conditions in inflammatory bowel disease. Extra weight, high blood pressure, diabetes, fatty liver, and cardiovascular disease are increasingly common in people with bowel inflammation. These conditions affect disease activity, drug response, surgery, and quality of life, yet guidance for their care rests on scattered findings.

The protocol combines three systematic reviews with a structured expert consensus using the RAND/UCLA appropriateness method. The reviews cover how obesity affects bowel disease outcomes, how large the cardiometabolic burden is, and how such conditions should be managed. An international panel of gut specialists, surgeons, hormone and liver experts, cardiologists, and dietitians will rate statements on a 9-point scale. Agreement is judged with a standard disagreement index. The guidance is meant to direct everyday practice and mark where research is most needed.

Catalog record

CREATORJalpa Devi, Sami Samaan, Priya Sehgal, Mouhand Mohamed, Matthew Vincent, Shannon Coombs, Michelle Doering, Edward L Barnes, Amanda M Johnson, Andres J Yarur, Parakkal Deepak
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE28 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13218099

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