The Role of Alpha-1 Antitrypsin in the Pathophysiology and Treatment of Inflammatory Lung Diseases
Daniella A Spittle, Alice M Turner · 2026
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Description
Daniella A. Spittle and Alice M. Turner present a 2026 review of alpha-1 antitrypsin, a blood protein best known for shielding the lungs from digestive enzymes released by immune cells. When the protein is missing or overwhelmed, that protection fails and lung tissue is slowly destroyed.
The review covers the protein's wider talents beyond enzyme blocking: calming inflammation, steering immune cells, and resisting cell death and oxidative stress. Deficiency-driven emphysema is the proven indication for replacement therapy, which is already in clinical use. The authors then examine whether the same treatment could help in bronchiectasis, cystic fibrosis, and interstitial lung diseases, where protease burden runs high even without the genetic defect. They weigh the emerging evidence for widening its use.
Catalog record
| CREATOR | Daniella A Spittle, Alice M Turner |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |