Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription
Shun-Ching Wang, Chang-Chih Hsieh, Tzu-Chun Yuan, Shan-Meng Lin, Chia-Wei Chen, Chih-Chun Chang, Shih-Chun Huang, En-Chi Wang, Yu-Jhen Huang, Ming-Hsi Chiang, Yih-Chern Horng, Ming-Hon Hou · 2026
Read Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription by Shun-Ching Wang, Chang-Chih Hsieh, Tzu-Chun Yuan, Shan-Meng Lin, Chia-Wei Chen, Chih-Chun Chang, Shih-Chun Huang, En-Chi Wang, Yu-Jhen Huang, Ming-Hsi Chiang, Yih-Chern Horng, Ming-Hon Hou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13216744.txt.
Description
Wang and colleagues published in twenty twenty-six a structural study of drug-like molecules that wedge into unusual DNA junctions. Most DNA is a double helix, but three-stranded junctions also form. The team studied two compounds that combine a weak and a strong flat ring system. Crystal structures show how they grip a three-stranded junction. The grip distorts the DNA and breaks the junction's integrity in a local way.
One compound, with a four-carbon linker, fit the junction best. Its strong ring mainly blocked an enzyme that cancer cells need. Its weak ring mainly suppressed several cancer-linked genes. In mouse tumors of colon and lung origin, it worked potently with little liver harm. The work marks triplex junctions as real drug targets.
Catalog record
| CREATOR | Shun-Ching Wang, Chang-Chih Hsieh, Tzu-Chun Yuan, Shan-Meng Lin, Chia-Wei Chen, Chih-Chun Chang, Shih-Chun Huang, En-Chi Wang, Yu-Jhen Huang, Ming-Hsi Chiang, Yih-Chern Horng, Ming-Hon Hou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |