LISS enables immune evasion of colorectal cancers irrespective of MSI status
Qingyu Lin, Xingwen Wang, Weixu Zhao, Shiying Song, Yi Zhang, Jiangwen Ma, Tianyu Li, Yuhan Wei, Minqiao Lu, Guixue Hou, Meiqi Wang, Hao Liu, Shanliang Zheng, Olga Burenina, Zhiyuan Xiang, Li Li, Jiaqi Zhu, Ying Hu · 2026
Read LISS enables immune evasion of colorectal cancers irrespective of MSI status by Qingyu Lin, Xingwen Wang, Weixu Zhao, Shiying Song, Yi Zhang, Jiangwen Ma, Tianyu Li, Yuhan Wei, Minqiao Lu, Guixue Hou, Meiqi Wang, Hao Liu, Shanliang Zheng, Olga Burenina, Zhiyuan Xiang, Li Li, Jiaqi Zhu, Ying Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13216641.txt.
Description
Qingyu Lin and co-authors present a 2026 cancer immunology study naming a long non-coding RNA, LISS, that helps colorectal tumours hide from the immune system. Checkpoint immunotherapy fails most colorectal patients, including many whose tumours look immunologically promising, so new brakes are worth hunting.
LISS runs high in colorectal cancers and predicts poor survival. In experiments it blunted T cell killing regardless of the tumour's microsatellite status. Mechanistically, LISS grips the enzyme CamKIIγ and stops it phosphorylating STAT1 at a key site, which lowers production of the MHC-I molecules that display tumour fragments to T cells. Silencing LISS with antisense drugs restored MHC-I and improved checkpoint therapy responses in mice. Patient samples showed the expected inverse pattern.
Catalog record
| CREATOR | Qingyu Lin, Xingwen Wang, Weixu Zhao, Shiying Song, Yi Zhang, Jiangwen Ma, Tianyu Li, Yuhan Wei, Minqiao Lu, Guixue Hou, Meiqi Wang, Hao Liu, Shanliang Zheng, Olga Burenina, Zhiyuan Xiang, Li Li, Jiaqi Zhu, Ying Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |