Gene- and subtype-dependent prognostic impact of ras pathway mutations in acute myeloid leukemia: a cohort study of 2,500 patients
Heng Shen, Yan Hui, Yuntao Liu, Shouyun Li, Dong Lin, Qiuyun Fang, Ying Wang, Benfa Gong, Chunlin Zhou, Kaiqi Liu, Guangji Zhang, Xiaoyuan Gong, Shaowei Qiu, Bingcheng Liu, Ying Wang, Yingchang Mi, Yan Li, Jianxiang Wang, Hui Wei · 2026
Read Gene- and subtype-dependent prognostic impact of ras pathway mutations in acute myeloid leukemia: a cohort study of 2,500 patients by Heng Shen, Yan Hui, Yuntao Liu, Shouyun Li, Dong Lin, Qiuyun Fang, Ying Wang, Benfa Gong, Chunlin Zhou, Kaiqi Liu, Guangji Zhang, Xiaoyuan Gong, Shaowei Qiu, Bingcheng Liu, Ying Wang, Yingchang Mi, Yan Li, Jianxiang Wang, Hui Wei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13216541.txt.
Description
Heng Shen and co-authors present a 2026 letter analysing mutations in the RAS signalling pathway across 2,500 patients with acute myeloid leukaemia treated at one Chinese centre. Whether these common mutations worsen prognosis has been disputed, partly because older studies were small.
Just over a third of patients carried at least one RAS pathway mutation, with NRAS the most frequent, followed by KRAS, PTPN11, CBL, and NF1. Mutated groups showed higher white blood cell counts, fitting the pathway's growth-driving role. Risk class distribution differed by gene: KRAS and NF1 clustered in adverse-risk disease, NRAS in favourable-risk. The mutations also kept characteristic company, with NRAS excluding other RAS mutations while PTPN11 travelled with NPM1 and DNMT3A changes.
Catalog record
| CREATOR | Heng Shen, Yan Hui, Yuntao Liu, Shouyun Li, Dong Lin, Qiuyun Fang, Ying Wang, Benfa Gong, Chunlin Zhou, Kaiqi Liu, Guangji Zhang, Xiaoyuan Gong, Shaowei Qiu, Bingcheng Liu, Ying Wang, Yingchang Mi, Yan Li, Jianxiang Wang, Hui Wei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |