Impaired Neuregulin 1 Processing is Associated with Synaptic and Behavioral Abnormalities in a Prenatal Valproic Acid Model of Autism
Yu-Jin Kim, Han-Byeol Kim, Hyo-Min Lim, Yoori Choi, Ran-Sook Woo · 2026
Read Impaired Neuregulin 1 Processing is Associated with Synaptic and Behavioral Abnormalities in a Prenatal Valproic Acid Model of Autism by Yu-Jin Kim, Han-Byeol Kim, Hyo-Min Lim, Yoori Choi, Ran-Sook Woo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13215460.txt.
Description
Yu-Jin Kim and co-authors present a 2026 rat study linking a growth signal's faulty trimming to autism-like traits. Pups exposed before birth to a drug called valproic acid form a known model of autism. A brain signal, neuregulin 1, must be cut by scissor enzymes to work. In exposed pups, the cut form fell while the gene's output held steady, and the scissors themselves ran low.
Signal flow past the cut point weakened, spine growth on brain cells stalled, and support proteins dropped. Pups showed odd acts across social, repeat, and sense tests. A dose of the ready signal in the teen phase eased repeat acts in both sexes. Social gains showed mostly in males. Trimming faults may be a drug aim in some autism paths.
Catalog record
| CREATOR | Yu-Jin Kim, Han-Byeol Kim, Hyo-Min Lim, Yoori Choi, Ran-Sook Woo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |