CD1D knockout swine are permissive to African swine fever virus genotype II infection
Daniel Madden, Jessie D. Trujillo, Shanmugasundaram Elango, Isaac Fitz, Chester D. McDowell, Patricia Assato, Eulim Lyoo, Taeyong Kwon, Konner Cool, Yonghai Li, Franco Matias Ferreyra, Natasha N. Gaudreault, Igor Morozov, Kiho Lee, John Driver, Juergen A. Richt · 2026
Read CD1D knockout swine are permissive to African swine fever virus genotype II infection by Daniel Madden, Jessie D. Trujillo, Shanmugasundaram Elango, Isaac Fitz, Chester D. McDowell, Patricia Assato, Eulim Lyoo, Taeyong Kwon, Konner Cool, Yonghai Li, Franco Matias Ferreyra, Natasha N. Gaudreault, Igor Morozov, Kiho Lee, John Driver, Juergen A. Richt (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13215427.txt.
Description
Daniel Madden led this 2026 animal study on African swine fever, a deadly virus disease of pigs. The team asked whether a pig protein called CD1d helps the virus enter cells, since blocking its gene in cell cultures had cut virus growth.
The researchers used gene editing to breed pigs that lack CD1d, then infected them with a strong type II strain of the virus. The edited pigs became just as sick as normal pigs, with no real difference in deaths, virus levels in blood and tissues, or organ damage. The work shows that CD1d is not required for this virus strain to cause severe disease in live pigs.
Catalog record
| CREATOR | Daniel Madden, Jessie D. Trujillo, Shanmugasundaram Elango, Isaac Fitz, Chester D. McDowell, Patricia Assato, Eulim Lyoo, Taeyong Kwon, Konner Cool, Yonghai Li, Franco Matias Ferreyra, Natasha N. Gaudreault, Igor Morozov, Kiho Lee, John Driver, Juergen A. Richt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46678 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |