Epstein–Barr virus reprograms immune escape in nasopharyngeal carcinoma
Qifang Liu, Yujing Tong, Tingting Sun, Linxi He, Xuewen Xu, Kai You · 2026
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Description
Qifang Liu and colleagues review in 2026 how the Epstein-Barr virus teaches a throat cancer to hide from the immune system. Nasopharyngeal carcinoma grows in an immune-rich setting yet stays oddly tolerant, which helps explain its weak response to immunotherapy.
Viral proteins switch on two signalling routes that flood the tumour with cytokines, re-educate immune cells, and raise several checkpoint brakes at once. T cells falter, suppressive myeloid cells gather, and other cells are shut out by stromal barriers. Blocking only the famous PD-1 brake therefore disappoints. The authors survey strategies that strike viral signalling and host immunity together, aiming to reopen the tumour to immune attack.
Catalog record
| CREATOR | Qifang Liu, Yujing Tong, Tingting Sun, Linxi He, Xuewen Xu, Kai You |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |