Position-dependent feedback drives scaling and robustness of morphogen gradients
Lewis Scott Mosby, Zena Hadjivasiliou · 2026
Read Position-dependent feedback drives scaling and robustness of morphogen gradients by Lewis Scott Mosby, Zena Hadjivasiliou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13214045.txt.
Description
Lewis Scott Mosby and Zena Hadjivasiliou model how a growth signal keeps its shape as embryos grow. Their 2026 paper studies morphogen gradients, chemical slopes that tell cells where they are. Such gradients often scale with tissue size and shrug off noise, a twin feat any good model must explain.
The accepted story needs a helper molecule, the expander, spread evenly with position-free feedback. Fresh data show expanders are not even at all. The authors repair the mechanism so feedback can vary with position and still deliver scaling. Their math ties scaling and toughness together point by point across the tissue. Spread-out expanders beat even ones, lifting both traits everywhere at once, and the expander's range can be tuned to choose where precision lands.
Catalog record
| CREATOR | Lewis Scott Mosby, Zena Hadjivasiliou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |