Clinical significance and functional characterization of RRN3 in gastric cancer: insights from pan-cancer analysis and experimental validation
Ruofan He, Qingqing Xing, Songyi Liu, Shiwei Lin, Xiang Lin, Jianxin Ye · 2026
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Description
Ruofan He and co-authors examine a ribosome-building protein, RRN3, as a marker and driver in stomach cancer, in a 2026 study. RRN3 sits in the nucleolus and is required to make ribosomes. Its role across cancers was ill defined. Fast-growing tumors crave ribosome production, so the link is plausible.
Public databases supplied expression, survival, and mutation data across cancer types. Immune features and drug-response profiles were mapped too. Lab experiments then tested the protein's function directly. Stomach cancer received the deepest attention. The work weighs RRN3 as a diagnostic and prognostic sign. It also probes whether blocking it could slow tumors. Oncologists gain a candidate target with broad data behind it.
Catalog record
| CREATOR | Ruofan He, Qingqing Xing, Songyi Liu, Shiwei Lin, Xiang Lin, Jianxin Ye |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |