A honeysuckle-decorated nanoimmunomodulator hijacks Macrophage-BMSC crosstalk to promote arthritic regeneration
Yuan Ma, Shan He, Hanzhong Liu, Jinye Zhang, Wenguo Huang, Yuan Gu, Naiqian Cui, Jikun Qian, Mincheng Lu, Daorong Xu, Zhiqing Li, Bin Yu · 2026
Read A honeysuckle-decorated nanoimmunomodulator hijacks Macrophage-BMSC crosstalk to promote arthritic regeneration by Yuan Ma, Shan He, Hanzhong Liu, Jinye Zhang, Wenguo Huang, Yuan Gu, Naiqian Cui, Jikun Qian, Mincheng Lu, Daorong Xu, Zhiqing Li, Bin Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13213683.txt.
Description
Yuan Ma and colleagues dress a nanozyme in honeysuckle extract to heal arthritic joints, in work from 2026. Osteoarthritis festers when macrophages stay inflamed and stem cells fail to rebuild cartilage. A ruthenium cluster wearing plant flavonoids mimics two cleanup enzymes at once.
The particle mops up reactive oxygen and calms the joint immune loop from two sides. It shields stem cells from a fiery death mode and blocks their alarm signal to macrophages. Stem cells then migrate better, build cartilage, and nudge macrophages toward healing mode. In mice with cut ligament joints, shots rebuilt cartilage and smoothed gait. Chemistry maps show a shift toward calming fat pathways in treated joints.
Catalog record
| CREATOR | Yuan Ma, Shan He, Hanzhong Liu, Jinye Zhang, Wenguo Huang, Yuan Gu, Naiqian Cui, Jikun Qian, Mincheng Lu, Daorong Xu, Zhiqing Li, Bin Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |