Heat stress induces ferroptosis in intramuscular preadipocytes of Hu sheep via activation of the TNF-α/NF-κB/GPX4 signaling axis
Shaoqiang Wu, Yirong Wei, Zhuangzhuang Han, Haien He, Jun Lu, Yishan Liang, Lianghuan Tang, Jianwei Zou, Yu Zhang, Yanna Huang, Qinyang Jiang · 2026
Read Heat stress induces ferroptosis in intramuscular preadipocytes of Hu sheep via activation of the TNF-α/NF-κB/GPX4 signaling axis by Shaoqiang Wu, Yirong Wei, Zhuangzhuang Han, Haien He, Jun Lu, Yishan Liang, Lianghuan Tang, Jianwei Zou, Yu Zhang, Yanna Huang, Qinyang Jiang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13213671.txt.
Description
Shaoqiang Wu and ten colleagues trace how heat stress kills the fat precursor cells that marble sheep meat, and why. High temperatures damage Hu sheep metabolism and reduce intramuscular fat, a prized quality trait. In cultured preadipocytes, heat raised inflammatory signals including TNF-alpha and switched on the NF-kappaB pathway.
That cascade suppressed GPX4, the enzyme that guards cells against a rust-like death called ferroptosis. Iron and peroxidized lipids accumulated, and the cells died. Blocking inflammation or the pathway restored GPX4 and rescued fat deposition. The findings nominate this inflammatory signaling axis as an intervention target for protecting meat quality in a warming climate.
Catalog record
| CREATOR | Shaoqiang Wu, Yirong Wei, Zhuangzhuang Han, Haien He, Jun Lu, Yishan Liang, Lianghuan Tang, Jianwei Zou, Yu Zhang, Yanna Huang, Qinyang Jiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |