Region-specific microglial alterations in the acoustic startle circuit in Shank3 mice
Xin Ren, Robbert Havekes, Martien JH Kas · 2026
Read Region-specific microglial alterations in the acoustic startle circuit in Shank3 mice by Xin Ren, Robbert Havekes, Martien JH Kas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13213229.txt.
Description
Immune cell shifts in a sound-startle circuit are mapped in Shank3 mice by Xin Ren, Robbert Havekes, and Martien Kas in work dated 2026. Shank3 loss models autism-linked traits, with odd sound and touch replies. Past work dwelt on neurons and skipped glia, the brain's support cells. The team read microglia, the brain's own immune cells, in six circuit zones plus one control zone.
One zone showed more of a microglia marker, and one showed more cells. No zone showed full immune flare by shape or a second marker. The shifts look circuit-bound, not brain-wide. Glia may tune some sensory paths in this model.
Catalog record
| CREATOR | Xin Ren, Robbert Havekes, Martien JH Kas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |