CELF2-dependent RNA Regulation Supports Cortical Architecture and Synaptic Stability During Early Brain Development
Ishana Syed, Jing Jiang, Su-Hyuk Ko, Shaoting Chen, Zhao Zhang, Zhijie Liu, Lizhen Chen · 2026
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Description
Ishana Syed and colleagues report in 2026 that a protein which edits RNA messages is essential for building a healthy young brain. Mice born without the protein, named CELF2, died soon after birth and showed disorganised cortex development.
Sequencing found widespread changes in gene activity and in how messages were spliced in the knockout brains. One key neuronal gene dropped sharply, matching evidence that CELF2 binds its message directly. Immature neuron counts fell, upper cortical layers thinned, and a specific neuron group shrank. Experiments in tiny worms partly rescued synapse defects with the human counterpart gene, suggesting a conserved role in wiring the nervous system.
Catalog record
| CREATOR | Ishana Syed, Jing Jiang, Su-Hyuk Ko, Shaoting Chen, Zhao Zhang, Zhijie Liu, Lizhen Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |