Manganese-doped nano-hydroxyapatite enhances CF/PEEK osseointegration via immunomodulation-osteogenesis coupling
Jiajun Liu, Zhenghao Li, Xuening Chen, Kai Zhang, Xiangdong Zhu, Bo Yuan · 2026
Read Manganese-doped nano-hydroxyapatite enhances CF/PEEK osseointegration via immunomodulation-osteogenesis coupling by Jiajun Liu, Zhenghao Li, Xuening Chen, Kai Zhang, Xiangdong Zhu, Bo Yuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13211982.txt.
Description
Jiajun Liu and co-authors coat a plastic bone implant to help it bond with real bone in a study from 2026. Carbon-fiber PEEK matches bone stiffness and shows clearly on scans. Its surface, though, is biologically inert. Fibrous tissue walls it off, and implants loosen.
A manganese-doped mineral coating, nano-hydroxyapatite, was grown on the surface in place. Immune cells meeting the coating shifted to the calm, healing M2 type. Inflammatory signals dropped in co-culture tests. That friendlier immune mood couples with new bone growth. The coating thus sells the implant to the body twice: less rejection, more bonding. Large load-bearing repairs are the target use.
Catalog record
| CREATOR | Jiajun Liu, Zhenghao Li, Xuening Chen, Kai Zhang, Xiangdong Zhu, Bo Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |