Copy Number Alterations in Canine Urothelial Carcinomas: The Impact of Tumour Purity
Marielle Appenzeller, Heike Aupperle-Lellbach, Alexandra Kehl, Robert Klopfleisch, Simone de Brot · 2026
Read Copy Number Alterations in Canine Urothelial Carcinomas: The Impact of Tumour Purity by Marielle Appenzeller, Heike Aupperle-Lellbach, Alexandra Kehl, Robert Klopfleisch, Simone de Brot (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13211511.txt.
Description
Marielle Appenzeller and co-authors test how tumor purity affects a gene test for bladder cancer in dogs. Their 2026 study examines seventy-six confirmed tumor samples. The test hunts copy number changes on three chromosomes that are typical of this cancer, alongside a known mutation check.
About seventy-six percent of samples tested positive under the standard cut-off. Many near-miss cases cleared the bar on one of the two ratios used. Sensitivity rose with tumor share: samples with at least twenty percent tumor tissue tested positive eighty-four percent of the time, and eighty-nine percent at forty percent share. The authors warn that sparse tumor content and many neutral cells can hide the signal.
Catalog record
| CREATOR | Marielle Appenzeller, Heike Aupperle-Lellbach, Alexandra Kehl, Robert Klopfleisch, Simone de Brot |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |