Investigation of the Effects of Saffron on Neuroprotection and Circadian Rhythm in an In Vitro Parkinson’s Model
Ayse Aksoy, Duygu Deniz Usta, Atiye Seda Yar · 2026
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Description
Ayse Aksoy, Duygu Deniz Usta, and Atiye Seda Yar test whether a saffron compound protects nerve cells in a lab model of Parkinson's disease, in a study from 2026. The disease kills dopamine-making brain cells over time. The standard drug, levodopa, helps symptoms but can cause harm with long use.
The team used a human nerve-like cell line and a toxin that mimics the disease's damage. Cells were pre-treated with levodopa, the saffron compound safranal, or both, at many doses. Tests read cell survival, cell power centers, death signals, and cell cleaning markers. Low doses of both agents partly protected the cells and lowered death signals. The study also tracked genes of the daily body clock, which the disease often disrupts.
Catalog record
| CREATOR | Ayse Aksoy, Duygu Deniz Usta, Atiye Seda Yar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |