Assessment of pH-Responsive Ionisable Lipid Nanoparticles as Cisplatin Delivery Vehicles for Treating Cisplatin-Resistant Ovarian Cancer
Sarigama Rajesh, Gwo Yaw Ho, Ravindu Fernando, Poh Yi Gan, Jessica Wu, Jiali Zhai, Joshua D. Ooi, Calum J. Drummond, Nhiem Tran · 2026
Read Assessment of pH-Responsive Ionisable Lipid Nanoparticles as Cisplatin Delivery Vehicles for Treating Cisplatin-Resistant Ovarian Cancer by Sarigama Rajesh, Gwo Yaw Ho, Ravindu Fernando, Poh Yi Gan, Jessica Wu, Jiali Zhai, Joshua D. Ooi, Calum J. Drummond, Nhiem Tran (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13210445.txt.
Description
Ovarian cancer often stops answering to cisplatin, a mainstay drug, so Sarigama Rajesh and co-authors pack that drug into fat bubbles designed to release it in acid. Their 2026 study builds three such particle types, each with a different acid-sensing lipid. The particles were sized, charged, and x-rayed, then tested in mice carrying tumors grown from patient tissue.
Loading was fair for all three, at roughly sixty percent of the drug kept inside. Acid flipped the particles' inner structure, as hoped. The best type shrank tumors about sixty percent more than free cisplatin. But it also harmed the mice, causing weight loss plus lung and kidney damage. The team says the design needs safety work before any clinical use.
Catalog record
| CREATOR | Sarigama Rajesh, Gwo Yaw Ho, Ravindu Fernando, Poh Yi Gan, Jessica Wu, Jiali Zhai, Joshua D. Ooi, Calum J. Drummond, Nhiem Tran |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |