Perioperative Immunonutrition for Elective Surgery: Review of Mechanisms, Summary of Evidence, and Future Directions
Laura Perez Arteaga, D. Dante Yeh · 2026
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Description
Laura Perez Arteaga and Dante Yeh review the practice of feeding surgery patients special immune-modulating nutrients. They find the evidence messier than guidelines suggest. Surgical trauma unleashes metabolic and inflammatory stress. Its size tracks the operation and the patient's baseline nutrition. Immunonutrition adds arginine, glutamine, omega-3 fats, and nucleotides to modulate that response.
Decades of trials and meta-analyses point both ways. They are tangled by products, protocols, and populations that differ. Recent rigorous, independently funded trials found no benefit. That casts doubt on past positive results and on current recommendations. The team sort the mechanisms and the evidence, and mark where selected patients might still gain. Their bottom line is a call for cleaner trials before routine adoption.
Catalog record
| CREATOR | Laura Perez Arteaga, D. Dante Yeh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |