MSC-Derived Apoptotic Vesicles Restore Bone Marrow Niche Homeostasis in Postmenopausal Osteoporosis by miRNA-Mediated Suppression of MAPK and NF-κB Signaling Nodes
Zhiwen Tu, Haolin Wu, Youxi Jiang, Xinxin Li, Zhiqing Huang, Songtao Shi, Ruibao Ren · 2026
Read MSC-Derived Apoptotic Vesicles Restore Bone Marrow Niche Homeostasis in Postmenopausal Osteoporosis by miRNA-Mediated Suppression of MAPK and NF-κB Signaling Nodes by Zhiwen Tu, Haolin Wu, Youxi Jiang, Xinxin Li, Zhiqing Huang, Songtao Shi, Ruibao Ren (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13210132.txt.
Description
Zhiwen Tu and colleagues tested stem cell vesicles against bone loss in 2026. After menopause, bone thins as marrow cells age and inflame. Tiny packets shed by dying stem cells may calm that process. The team compared those packets with the better-known exosome packets. Tests ran in mice lacking ovaries and in aged human marrow cells. Small RNA reads compared the cargo of both packet types. The team tracked inflammatory output and bone-forming ability.
The dying-cell packets eased bone loss more than exosomes. They also cut aging-related inflammatory signals more strongly. Their cargo held a rich cluster of small regulatory RNAs. Those RNAs target two growth control proteins. Treated cells showed lower levels of both proteins. Two inflammatory signaling routes also quieted down. Marrow inflammation eased, and bone-forming capacity held up. The authors propose the packets as a cell-free therapy lead.
Catalog record
| CREATOR | Zhiwen Tu, Haolin Wu, Youxi Jiang, Xinxin Li, Zhiqing Huang, Songtao Shi, Ruibao Ren |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |