Novel Cinnamaldehyde Hydrazones: Design, In Silico Evaluation, Synthesis, and Cytotoxic Activity
Boryana Nikolova-Mladenova, Rositsa Mihaylova, Mariyana Atanasova · 2026
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Description
Boryana Nikolova-Mladenova and co-authors designed new cancer-fighting candidates in two thousand twenty-six. They started from cinnamaldehyde, the compound that flavors cinnamon. Its shape is a handy base for building drug-like molecules. The team attached new side groups to form hydrazone compounds. Computer screens ran first to weed out weak designs.
Eight new compounds were then made in a single reaction step. Lab spectra confirmed each target structure had formed. Software rated their drug-like traits and likely body handling. Cell tests measured how strongly they kill cancer cells. The study mixes computer design with hands-on synthesis. It offers fresh starting points for anticancer drug work. Further tests will show which leads deserve animal studies.
Catalog record
| CREATOR | Boryana Nikolova-Mladenova, Rositsa Mihaylova, Mariyana Atanasova |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |