Characterization of Isoorientin and Paeoniflorin as Botanical Glucocorticoid Receptor Modulators from White Peony and Chasteberry
Rasha M. Bashatwah, Luke T. Jesikiewicz, Alyssa L. Hardy, José A. Villegas, Kailiang Li, Brian T. Murphy, Joanna E. Burdette · 2026
Read Characterization of Isoorientin and Paeoniflorin as Botanical Glucocorticoid Receptor Modulators from White Peony and Chasteberry by Rasha M. Bashatwah, Luke T. Jesikiewicz, Alyssa L. Hardy, José A. Villegas, Kailiang Li, Brian T. Murphy, Joanna E. Burdette (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13209654.txt.
Description
Bashatwah and six co-authors study two plant compounds as hormone receptor modulators, in work from twenty twenty-six. Botanical supplements are studied more and more for women health concerns. Compounds that tune progesterone signaling may help with endometriosis and preterm birth.
Progesterone drugs often cross react with the glucocorticoid receptor, causing side effects. Isoorientin and paeoniflorin, from chasteberry and white peony, were tested as botanical modulators of that second receptor. Such tuning could keep the benefit with fewer steroid side effects. The work is early compound test work. It is a step toward plant derived hormone drugs.
Catalog record
| CREATOR | Rasha M. Bashatwah, Luke T. Jesikiewicz, Alyssa L. Hardy, José A. Villegas, Kailiang Li, Brian T. Murphy, Joanna E. Burdette |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |