Koilocytosis in LSIL Cytology Has Limited Predictive Value for CIN2+ in HPV-Positive Women: Implications for Risk-Based Cytology Triage
Yukimi Misawa, Shuichi Mizuno, Saeka Honda, Ruku Shinohara, Koki Kikuchi, Rei Settsu, Kaori Okayama, Masahiko Fujii, Mizue Oda, Mitsuaki Okodo · 2026
Read Koilocytosis in LSIL Cytology Has Limited Predictive Value for CIN2+ in HPV-Positive Women: Implications for Risk-Based Cytology Triage by Yukimi Misawa, Shuichi Mizuno, Saeka Honda, Ruku Shinohara, Koki Kikuchi, Rei Settsu, Kaori Okayama, Masahiko Fujii, Mizue Oda, Mitsuaki Okodo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13209615.txt.
Description
Misawa and co-authors test if koilocytes in smears predict high-grade cervical lesions. Koilocytes are a classic sign of HPV infection in cells. The team reviewed 157 HPV-positive women with low-grade smears. Biopsy results were on hand for 140 of them. Koilocytes appeared in 59.2 percent of cases.
High-grade lesions sat in 10.7 percent of koilocyte-positive cases. They sat in 28.6 percent of koilocyte-negative cases instead. Koilocyte cases also took longer to clear to normal. The authors say the sign marks active infection, not risk. Dropping it from triage rules could raise test precision.
Catalog record
| CREATOR | Yukimi Misawa, Shuichi Mizuno, Saeka Honda, Ruku Shinohara, Koki Kikuchi, Rei Settsu, Kaori Okayama, Masahiko Fujii, Mizue Oda, Mitsuaki Okodo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |