Glutamine Starvation Induces Ferroptosis in NSCLC via AMPK/PDZD8-Mediated Ferritinophagy
Hong Chen, Xiaoying Wu, Manting Zhu, Ying Cheng, Qing Feng · 2026
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Description
Chen and co-authors show that starving lung cancer cells of one nutrient can push them into a distinctive form of cell death. Non-small cell lung cancer depends heavily on the amino acid glutamine. The death pathway is ferroptosis, an iron-driven process, and the route to it runs through the cell digesting its own iron stores.
In cell cultures and mouse tumors, removing glutamine slowed growth, migration, and colony formation. A cellular energy sensor, AMPK, switched on and raised levels of a protein called PDZD8, which drove the iron-store digestion that feeds ferroptosis. Raising PDZD8 alone triggered the same death. The authors propose dietary glutamine restriction as a possible supporting therapy.
Catalog record
| CREATOR | Hong Chen, Xiaoying Wu, Manting Zhu, Ying Cheng, Qing Feng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |