Autophagy and metabolic homeostasis: Exploration in obesity-related metabolic diseases (Review)
Chenglin Lu, Xiangyu Qi, Yuting Tong, Peng Lu, Dandan Luo, Qingbo Guan, Chunxiao Yu · 2026
Read Autophagy and metabolic homeostasis: Exploration in obesity-related metabolic diseases (Review) by Chenglin Lu, Xiangyu Qi, Yuting Tong, Peng Lu, Dandan Luo, Qingbo Guan, Chunxiao Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13209479.txt.
Description
Chenglin Lu and colleagues review how autophagy, the cell's reuse system, goes wrong in obesity-related metabolic diseases. Autophagy seals excess nutrients, toxic protein clumps, damaged organelles, and invading microbes in double-membrane vesicles. It sends them to lysosomes for degradation. Two decades of research show it maintains the cell's inner balance. It also adds to metabolic disease growth.
In obesity, nutrient imbalance jams autophagy through multiple mechanisms, making organ damage worse. Yet under certain conditions, blocking it helps, easing some harmful consequences. The review covers type two diabetes, fatty liver disease, and atherosclerosis in turn. It discusses in set order what autophagy is and its types. It covers how nutrients guide it, and the molecular mechanisms of its imbalance in each disease. It closes with drugs aimed at the pathway.
Catalog record
| CREATOR | Chenglin Lu, Xiangyu Qi, Yuting Tong, Peng Lu, Dandan Luo, Qingbo Guan, Chunxiao Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |