Comparative Protective Effects of Melatonin and Apigenin Against Paclitaxel-Induced Testicular Injury in Rats: Oxidative Stress, DNA Damage, Apoptosis, and NF-κB Signaling
Faruk Saydam, Merve Altuntoprak, Enes Bahadir Bay, Tolga Mercantepe, Atilla Topcu, Sibel Mataraci Karakas · 2026
Read Comparative Protective Effects of Melatonin and Apigenin Against Paclitaxel-Induced Testicular Injury in Rats: Oxidative Stress, DNA Damage, Apoptosis, and NF-κB Signaling by Faruk Saydam, Merve Altuntoprak, Enes Bahadir Bay, Tolga Mercantepe, Atilla Topcu, Sibel Mataraci Karakas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13209436.txt.
Description
Two natural compounds are pitted against chemotherapy damage to the testes in a 2026 rat study headed by Faruk Saydam. The research article contrasts melatonin and the plant flavonoid apigenin to shield rats from paclitaxel, scoring oxidative stress, DNA damage, cell death signals, and sperm-producing tubule health across seven groups.
Paclitaxel raised lipid peroxidation, drained a key antioxidant, and visibly wrecked the seminiferous tubules of untreated rats. Melatonin repaired the redox balance and preserved tissue structure best in the noted checks. Apigenin also cut that damage and improved tissue scores, though it lowered those defenses in otherwise healthy animals, an effect that depends on context, the authors flag.
Catalog record
| CREATOR | Faruk Saydam, Merve Altuntoprak, Enes Bahadir Bay, Tolga Mercantepe, Atilla Topcu, Sibel Mataraci Karakas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |