Marine Bioactive Peptides for Colorectal Cancer Therapy: Mechanisms, Therapeutic Potential, and Translational Challenges
Yueyang Lu, Guixiao Wang, Mei Zhou, Tianbao Chen, Zhimin Fan · 2026
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Description
Bowel cancer remains a leading killer, and treatments are often blunted by drug resistance, harsh side effects, and relapse. Yueyang Lu and co-authors review a hopeful class of candidates: peptides from marine life. Sea organisms make an unusually varied stock of these small proteins. Many kill bowel cancer cells in the lab while sparing normal cells. They trigger cell suicide, block division, stop spread, and seal off the tumour's blood supply.
The catch is delivery: peptides break down fast, absorb poorly, and are hard to make at scale. The review surveys fixes now in play, from chemical tweaks and ring-shaped designs to nano-carriers, smart delivery systems, and AI-guided design. The authors map sources, structures, and test results, and argue that joining these crafts is the path to a real marine-peptide drug for bowel cancer.
Catalog record
| CREATOR | Yueyang Lu, Guixiao Wang, Mei Zhou, Tianbao Chen, Zhimin Fan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |