Development of HPMC-Based Hard Capsules with Rapid Disintegration Across Simulated Gastrointestinal pH Conditions: Formulation Design, Process Optimization, and Disintegration Mechanism of the HPMC/GG/ι-C Ternary System
Yuting Dong, Songlin Ye, Xiaojun Hong, Yafang Shi, Youcheng Liu, Xueqin Zhang, Jing Ye, Meitian Xiao · 2026
Read Development of HPMC-Based Hard Capsules with Rapid Disintegration Across Simulated Gastrointestinal pH Conditions: Formulation Design, Process Optimization, and Disintegration Mechanism of the HPMC/GG/ι-C Ternary System by Yuting Dong, Songlin Ye, Xiaojun Hong, Yafang Shi, Youcheng Liu, Xueqin Zhang, Jing Ye, Meitian Xiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13208135.txt.
Description
Gelatin capsules come from animals, so plant-based shells are in demand, yet the leading plant material makes weak, costly capsules. Yuting Dong and co-authors tackled that problem in 2026 with a three-part blend built on the plant polymer HPMC, plus gellan gum and a seaweed extract. They tuned the recipe and the process with systematic tests.
The finished capsules fell apart within fifteen minutes across four acidity levels that mimic the gut, meeting the 2025 Chinese standard. Two test drugs dissolved from them as well as from store-bought gelatin capsules. Microscope images traced how the shell breaks down. The authors offer the blend as a low-cost route to making plant-based capsules at factory scale.
Catalog record
| CREATOR | Yuting Dong, Songlin Ye, Xiaojun Hong, Yafang Shi, Youcheng Liu, Xueqin Zhang, Jing Ye, Meitian Xiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |