Aglianico Grape Pomace Extract Reduces Cardiac Pacemaker Activity by Decreasing Hyperpolarization-Activated Current Density Independently of cAMP Signaling
Roberta De Zio, Maira Certini, Eugenia Pignataro, Daniela Russo, Simona Ida Scorza, Serena Milano, Giuseppe Procino, René Massimiliano Marsano, Maria Svelto, Isabella Maiellaro, Luigi Milella, Monica Carmosino, Andrea Gerbino · 2026
Read Aglianico Grape Pomace Extract Reduces Cardiac Pacemaker Activity by Decreasing Hyperpolarization-Activated Current Density Independently of cAMP Signaling by Roberta De Zio, Maira Certini, Eugenia Pignataro, Daniela Russo, Simona Ida Scorza, Serena Milano, Giuseppe Procino, René Massimiliano Marsano, Maria Svelto, Isabella Maiellaro, Luigi Milella, Monica Carmosino, Andrea Gerbino (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13208127.txt.
Description
Roberta De Zio and a large team test a grape waste extract on the heart's pacemaker cells. Their study was published in twenty twenty-six. The extract comes from Aglianico grape pomace and is rich in polyphenols known to guard the heart, but its direct electric effects were untested.
Two models were used: beating heart cells in dishes and the heart tube of fruit fly larvae. After two days of treatment, the heart cells fired less often, with a longer rest stretch between beats. The slowing traced to a weaker pacemaker current, not to changes in other currents or calcium balance. The effect did not run through the usual cAMP signal. The work suggests grape pomace compounds can tune heart rate at the cell level.
Catalog record
| CREATOR | Roberta De Zio, Maira Certini, Eugenia Pignataro, Daniela Russo, Simona Ida Scorza, Serena Milano, Giuseppe Procino, René Massimiliano Marsano, Maria Svelto, Isabella Maiellaro, Luigi Milella, Monica Carmosino, Andrea Gerbino |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |