Biologically Effective Dose-Optimized Multi-Intensity-Modulated Proton Therapy: A Biologically Comparable Alternative to Proton Arc Therapy
Nimita Shinde, Yanan Zhu, Wei Wang, Wangyao Li, Yuting Lin, Gregory N. Gan, Christopher Lominska, Ronny Rotondo, Ronald C. Chen, Hao Gao · 2026
Read Biologically Effective Dose-Optimized Multi-Intensity-Modulated Proton Therapy: A Biologically Comparable Alternative to Proton Arc Therapy by Nimita Shinde, Yanan Zhu, Wei Wang, Wangyao Li, Yuting Lin, Gregory N. Gan, Christopher Lominska, Ronny Rotondo, Ronald C. Chen, Hao Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13208107.txt.
Description
Nimita Shinde and co-authors propose a 2026 proton therapy planning method that mimics arc therapy without needing it. Proton arc therapy shapes dose tightly around a tumor, but it is not yet available in clinics. A practical stand in uses several fixed angle proton plans across fractions. Past versions of that stand in ignored how splitting dose across fractions changes its biological effect, so they were not truly comparable to arc plans.
Their method optimizes the biologically effective dose directly, building the fraction effect into planning from the start. Each fraction uses a small set of beam angles, and both tumor dose and organ dose are tuned per fraction. A two step solving method handles the hard optimization. The authors evaluate whether the result truly matches arc therapy on biological dose, which is the claim that sets their work apart.
Catalog record
| CREATOR | Nimita Shinde, Yanan Zhu, Wei Wang, Wangyao Li, Yuting Lin, Gregory N. Gan, Christopher Lominska, Ronny Rotondo, Ronald C. Chen, Hao Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |