Integrated Single-Cell and Bulk RNA Sequencing Identifies Macrophage Heterogeneity and Mitophagy-Related Biomarkers in Idiopathic Pulmonary Fibrosis
Chen Shang, Gao Huang · 2026
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Description
Chen Shang and Gao Huang report in 2026 on a lung disease that scars lung tissue and has no clear cause. They ask how immune cells called macrophages, and the clearing of worn out cell power plants, may shape the disease.
The authors join data from single cells and from whole tissue samples to sort the macrophages into groups. One group stood out, and two marker genes tied to it rose sharply in diseased lungs. The study links those genes to immune cell mixes in the lung, to cell cycle checks, and to nine drugs. It also tracks how the markers change as the cells mature.
Catalog record
| CREATOR | Chen Shang, Gao Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |