Histamine-Mediated Syndrome (HMS): Beyond Allergy and Therapeutic Potential of Immunoglobulin/Histamine Complex (IHC)
Hyuk Soon Kim, Geunwoong Noh · 2026
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Description
Hyuk Soon Kim and Geunwoong Noh define a histamine-driven syndrome reaching beyond classic allergy, in a 2026 review. Histamine acts through four receptors across many organs. Raised blood levels can spark symptoms in skin, gut, airways, and more. The authors gather conditions where that pattern appears. Allergy clinic regulars often carry higher baseline levels than expected.
Symptoms in distant organs may share one histamine root. That makes the syndrome easy to miss in routine care. A combined immunoglobulin and histamine product is reviewed as treatment. Reports describe its use in rhinitis and chronic hives. Wider histamine-driven complaints may also respond. The review proposes a clinical framework for spotting cases. Naming the syndrome is meant to sharpen diagnosis. Trials should now test the framework prospectively.
Catalog record
| CREATOR | Hyuk Soon Kim, Geunwoong Noh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |