Biofilm–Host Immune Crosstalk at the Diabetic Foot Ulcer Interface: Molecular Mechanisms, Immune Evasion, and Next-Generation Anti-Biofilm Strategies
Yu Han, Ye Yang · 2026
Read Biofilm–Host Immune Crosstalk at the Diabetic Foot Ulcer Interface: Molecular Mechanisms, Immune Evasion, and Next-Generation Anti-Biofilm Strategies by Yu Han, Ye Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13207914.txt.
Description
Yu Han and Ye Yang review a hard problem in diabetes care in a 2026 paper: foot ulcers that will not heal. These chronic wounds hold dense films of microbes called biofilms. The authors argue the wound should be seen as a meeting point between the biofilm and the host immune system, not as a germ problem alone. High blood sugar, poor blood flow, and nerve damage all help the films persist.
The review explains how the films dodge clearance. Their outer matrix shields them, and some bacteria hide inside host cells. Two immune fault lines stand out: overactive traps cast by white blood cells, and damage from a suppressed defense protein. The authors then weigh new anti-biofilm ideas, from blocking microbe signals to enzymes, viruses that infect bacteria, and immune directed drugs.
Catalog record
| CREATOR | Yu Han, Ye Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |