CA9-Targeted Liposomal Delivery of siETS1 Inhibits Clear Cell Renal Cell Carcinoma Progression by Disrupting the ETS1/MYC Regulatory Axis
Yuyang Ye, Jing Sun, Yizheng Zhang, Shenghan Wang, Zhaoqian Meng · 2026
Read CA9-Targeted Liposomal Delivery of siETS1 Inhibits Clear Cell Renal Cell Carcinoma Progression by Disrupting the ETS1/MYC Regulatory Axis by Yuyang Ye, Jing Sun, Yizheng Zhang, Shenghan Wang, Zhaoqian Meng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13207890.txt.
Description
A kidney cancer's surface flag becomes the delivery address for gene silencing in a 2026 study by Yuyang Ye. The research article targets carbonic anhydrase IX, abundant on clear cell renal carcinoma, with liposomes carrying small RNA against the transcription factor ETS1.
Genomic analyses first showed ETS1 and MYC switched on together in tumor cells, and bench experiments proved ETS1 directly turns MYC on. The team engineered a peptide that homes to the surface flag and decorated drug-loaded liposomes with it for delivery. The particles silenced the ETS1 and MYC axis and slowed tumor growth in cell lines, patient organoids, and mouse grafts.
Catalog record
| CREATOR | Yuyang Ye, Jing Sun, Yizheng Zhang, Shenghan Wang, Zhaoqian Meng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |